PXD025710-1

PXD025710 is an original dataset announced via ProteomeXchange.

Title	Characterization of the N- and C-terminal domain interface of the three main apoE isoforms
Description	Chemical cross-linking coupled to mass spectrometry was used to investigate the conformations of the apolipoprotein isoforms apoE2, apoE3, and apoE4. Cross-linking data was generated using the reagents disuccinimidyl suberate (DSS), pimelic dihydrazide (PDH), and 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMTMM) chloride. Intramolecular interactions derived from the cross-linking experiments were combined with molecular modeling approaches.
HostingRepository	PRIDE
AnnounceDate	2025-01-26
AnnouncementXML	Submission_2025-01-26_06:29:43.777.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Leitner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-29 05:40:56	ID requested
⏵ 1	2025-01-26 06:29:44	announced

Dataset with its publication pending

submitter keyword: Chemical cross-linking

DSS

PDH

DMTMM

apolipoprotein E

apoE

Alexander Leitner
contact affiliation	ETH Zurich, Institute of Molecular Systems Biology, Zurich, Switzerland
contact email	leitner@imsb.biol.ethz.ch
lab head
Alexander Leitner
contact affiliation	ETH Zurich, Institute of Molecular Systems Biology
contact email	leitner@imsb.biol.ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD025710

PRIDE project URI

• PRIDE
  1. PXD025710
     1. Label: PRIDE project
     2. Name: Characterization of the N- and C-terminal domain interface of the three main apoE isoforms