PXD025676-1

PXD025676 is an original dataset announced via ProteomeXchange.

Title	Suv4-20h2 protects from influenza virus infection through suppression of chromatin loop formation
Description	The spatial organization of chromatin is known to be highly dynamic in response to environmental stress. However, it remains unknown how chromatin dynamics contributes to or modulate the disease pathogenesis. Here we show that upon influenza virus infection, H4K20me3 methyltransferase Suv4-20h2 binds the viral protein NP, which results in the inactivation of the Suv4-20h2 and the dissociation of cohesin from Suv4-20h2. Inactivation of Suv4-20h2 by virus infection or genetic deletion, leads to active loop formation at HoxC8-HoxC6 through the loading of cohesin to this region. HoxC8 and HoxC6 in turn enhance viral replication by inhibiting the Wnt--catenin mediated interferon response. Importantly, loss of Suv4-20h2 augments the influenza pathology in vivo. Thus, Suv4-20h2 acts as a safeguard against influenza virus infection though the suppression of a cohesin-mediated loop formation.
HostingRepository	PRIDE
AnnounceDate	2021-05-13
AnnouncementXML	Submission_2021-05-13_03:21:11.293.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Masami Shiimori
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-27 22:39:42	ID requested
⏵ 1	2021-05-13 03:21:11	announced

Dataset with its publication pending

submitter keyword: Mouse, MEF, Suv-420h2, Influenza virus

Yumiko Imai
contact affiliation	Laboratory of the Regulation for Intractable Infectious Diseases, National Institute of Biomedical Innovation, Health and Nutrition, Japan
contact email	y-imai@nibiohn.go.jp
lab head
Masami Shiimori
contact affiliation	National Institute of Biomedical Innovation, Health and Nutrition
contact email	m-shiimori@nibiohn.go.jp
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD025676
     1. Label: PRIDE project
     2. Name: Suv4-20h2 protects from influenza virus infection through suppression of chromatin loop formation