PXD025519 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparative proteomics of paired human vocal fold and oral mucosa tissue |
Description | This dataset brief is about the descriptive proteomic comparison of human oral mucosa and vocal fold tissues by high-resolution mass spectrometry (CID-MS/MS). The vast majority of voice disorders is associated with changes of the unique but delicate tissue of the human vocal folds, wheras the ability to develop new effective treatment methods is significantly limited by the physical inaccessibility and the extremely rare occasion to gather healthy tissue biopsies. Therefore, oral mucosa reached specific interest for laryngological research, as the tissue harvesting process is less invasive and accompanied with faster healing and less scarring. Proteomic analysis of both tissues will provide a fundamental laryngological resource for the research community. Our study identifies a total of 1575 proteins detected within both tissues that are highly consistent in several crucial biological processes, cellular components, and molecular functions. |
HostingRepository | PRIDE |
AnnounceDate | 2021-12-30 |
AnnouncementXML | Submission_2021-12-30_14:23:09.093.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Barbara Darnhofer |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | maXis |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-04-21 02:43:07 | ID requested | |
⏵ 1 | 2021-12-30 14:23:09 | announced | |
Publication List
Grossmann T, Darnhofer B, Birner-Gruenberger R, Kirsch A, Gugatschka M, Descriptive proteomics of paired human vocal fold and buccal mucosa tissue. Proteomics Clin Appl, 16(2):e2100050(2022) [pubmed] |
Keyword List
submitter keyword: comparative proteomics, human tissue, oral mucosa, vocal folds |
Contact List
ruth birner-gruenberger |
contact affiliation | Ruth Birner-Gruenberger, Ph.D. Full Professor for Analytical Chemistry Vienna University of Technology Institute of Chemical Technologies and Analytics Getreidemarkt 9/E164 A-1060 Vienna Austria Associate Professor for Biochemistry Medical University of Graz Diagnostic and Research Institute of Pathology Stiftingtalstrasse 24 A-8010 Graz Austria |
contact email | ruth.birner-gruenberger@tuwien.ac.at |
lab head | |
Barbara Darnhofer |
contact affiliation | Omics Center Graz |
contact email | barbara.darnhofer@klinikum-graz.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/12/PXD025519 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025519
- Label: PRIDE project
- Name: Comparative proteomics of paired human vocal fold and oral mucosa tissue