PXD025440 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Exploration of peptides that are increased in the plasma of diabetic mice and are the substrate of dipeptidyl peptidase III |
Description | Diabetes mellitus (DM) causes the change in the components of the plasma, which may induce tissue and organ injuries, including the heart and kidney. In the diabetic model db/db mice, intravenous injection of purified dipeptidyl peptidase III (DPPIII) attenuated the heart and kidney damages provoked by DM without alteration in blood glucose level. This led us to hypothesize that there might be peptide(s) that are involved in the progression of the DM-mediated damages and are cleaved by DPPIII. To explore the peptides, the whole peptidomics analysis was conducted using tandem mass spectrometry, in which peptides derived from the plasma of PBS-infused C57BL/6 mice, PBS-infused db/db mice, and DPPIII-treated db/db mice were compared. All of the lists of the peptides in the three mouse groups were shown in the raw data formatted and excel files. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-17 |
AnnouncementXML | Submission_2022-02-17_00:37:59.512.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Akio Shimizu |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-04-16 06:19:58 | ID requested | |
⏵ 1 | 2022-02-17 00:38:00 | announced | |
Publication List
Komeno M, Pang X, Shimizu A, Molla MR, Yasuda-Yamahara M, Kume S, Rahman NIA, Soh JEC, Nguyen LKC, Ahmat Amin MKB, Kokami N, Sato A, Asano Y, Maegawa H, Ogita H, Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice. J Biol Chem, 296():100761(2021) [pubmed] |
Keyword List
submitter keyword: mouse, plasma, peptide, peptidase, diabetes mellitus |
Contact List
Hisakazu Ogita |
contact affiliation | Shiga University of Medical Science |
contact email | hogita@belle.shiga-med.ac.jp |
lab head | |
Akio Shimizu |
contact affiliation | Shiga University of Medical Science |
contact email | shimizua@belle.shiga-med.ac.jp |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD025440 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025440
- Label: PRIDE project
- Name: Exploration of peptides that are increased in the plasma of diabetic mice and are the substrate of dipeptidyl peptidase III