PXD025141-1

PXD025141 is an original dataset announced via ProteomeXchange.

Title	Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
Description	Accurate analysis of tissue-specific secretory proteins in blood plasma can provide valuable information regarding therapeutic target development but current approaches are mostly limited to ex vivo proteomic analysis. Here, we developed an in situ secretory protein labeling technology using endoplasmic reticulum-anchored TurboID (iSLET) and validated its utility in vivo by the successful identification of liver-specific secretory proteins in mouse plasma. iSLET is a promising new strategy that will facilitate the discovery of tissue-specific secretory proteins mediating interorgan communication in normal physiology and disease.
HostingRepository	PRIDE
AnnounceDate	2021-08-06
AnnouncementXML	Submission_2021-08-06_02:47:39.468.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD025141
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jong-Seo Kim
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-01 02:52:46	ID requested
⏵ 1	2021-08-06 02:47:39	announced
2	2024-10-22 05:24:23	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: TurboID, proximity labeling, proteomics

Jong-Seo Kim
contact affiliation	School of Biological Sciences, Seoul National Uuniversity
contact email	jongseokim@snu.ac.kr
lab head
Jong-Seo Kim
contact affiliation	School of Biological Sciences, Seoul National University
contact email	jongseokim@snu.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD025141

PRIDE project URI

• PRIDE
  1. PXD025141
     1. Label: PRIDE project
     2. Name: Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice