PXD025138-1

PXD025138 is an original dataset announced via ProteomeXchange.

Title	Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19
Description	SARS-CoV-2 infection poses a global health crisis. In parallel with the ongoing world effort to identify therapeutic solutions, there is a critical need for improvement in the prognosis of COVID-19. Here, we report plasma proteome finger print that predict high (hospitalized)and low risk(outpatients) cases of COVID-19 identified by a platform that combines machine learning with matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF MS) analysis. Sample preparation, MS and data analysis parameters were optimized to achieve an overall accuracy of 92%, sensitivity of 93%, and specificity of 92% in dataset without feature selection. Further on, we identified two distinct regions in the MALDI-TOF profile belonging to the same proteoforms. Unbiased discrimination of high and low-risk COVID-19patients employing a technology that is currently in clinical use may have a prompt application in the noninvasive prognosis of COVID-19. Further validation will consolidate its clinical utility.
HostingRepository	PRIDE
AnnounceDate	2021-06-22
AnnouncementXML	Submission_2021-06-21_22:38:55.477.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giuseppe Palmisano
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ultraflex

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-01 02:26:32	ID requested
⏵ 1	2021-06-21 22:38:55	announced

Dataset with its publication pending

ProteomeXchange project tag: Covid-19

submitter keyword: COVID-19, SARS-CoV-2, Mass spectrometry, Biomarker, Plasma, Prognosis

Giuseppe Palmisano
contact affiliation	GlycoProteomics Laboratory, Avenida Lineu Prestes 1374, sala 9, Butanta, Sao Paulo, SP, Brazil
contact email	palmisano.gp@gmail.com
lab head
Giuseppe Palmisano
contact affiliation	University of Sao Paulo
contact email	palmisano.gp@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD025138

PRIDE project URI

• PRIDE
  1. PXD025138
     1. Label: PRIDE project
     2. Name: Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19