PXD025107-1

PXD025107 is an original dataset announced via ProteomeXchange.

Title	Data on nucleoid-associated proteins isolated from Mycoplasma gallisepticum after intracellular infection
Description	Mycoplasma gallisepticum belongs to the class Mollicutes. It causes chronic respiratory disease in avian species. M. gallisepticum is characterized by lack of cell wall; reduced genome size and the volume of its nucleoid is comparable to the size of the whole cell. As a result of genome reduction, M. gallisepticum has a limited variety of DNA-binding proteins (DBP) and transcription factors. It was shown, however, that mycoplasmas demonstrate a wide range of differential expression in response to various stress factors, which promotes effective adaptation to unfavorable conditions. We assume that in the case of mycoplasmas, which are characterized by a combination of the reduction of known gene expression regulation systems and a high adaptive potential, the coordination of gene expression can be provided due to local changes in the structure and spatial organization of the chromosome. The study of the dynamic changes of the proteomic profile of M. gallisepticum nucleoid may assist in revealing its mechanisms of functioning, regulation of chromosome organization and stress adaptation including its changes upon invasion of the host cells.
HostingRepository	PRIDE
AnnounceDate	2021-03-31
AnnouncementXML	Submission_2021-03-31_03:13:41.114.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aleksandr Zubov
SpeciesList	scientific name: Mycoplasma gallisepticum S6; NCBI TaxID: 1006581;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-30 10:41:39	ID requested
⏵ 1	2021-03-31 03:13:41	announced

Dataset with its publication pending

submitter keyword: mycoplasma gallisepticum, intracellular infection, LC-MS/MS, shotgun proteomics, nucleoid-associated peoteins

Gleb Fisunov
contact affiliation	Lab of Proteome Research, Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia
contact email	herr.romanoff@gmail.com
lab head
Aleksandr Zubov
contact affiliation	Lab of Proteome Research, Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow
contact email	alexanderzubov@icloud.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD025107

PRIDE project URI

• PRIDE
  1. PXD025107
     1. Label: PRIDE project
     2. Name: Data on nucleoid-associated proteins isolated from Mycoplasma gallisepticum after intracellular infection