PXD025101-1

PXD025101 is an original dataset announced via ProteomeXchange.

Title	Contribution of IFIX to nuclear and cytoplasmic proteome changes during immune signaling
Description	IFIX is a nuclear DNA sensor that is known to induce cytokine expression in response to both cytoplasmic DNA and foreign DNA in the nucleus. Here, we examine the concomitant nuclear and cytoplasmic proteome changes that are driven by IFIX during immune response to viral infection and transfection of viral DNA. Furthermore, we identify the posttranslational modifications present on the IFIX protein during HSV-1 infection.
HostingRepository	PRIDE
AnnounceDate	2021-06-02
AnnouncementXML	Submission_2021-06-02_13:51:48.155.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tim Howard
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Human alphaherpesvirus 1; NCBI TaxID: 10298;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-30 03:42:44	ID requested
⏵ 1	2021-06-02 13:51:48	announced

Dataset with its publication pending

submitter keyword: Innate immunity, nuclear DNA sensor, IFIX, PTM

Ileana M Cristea
contact affiliation	Department of Molecular Biology, Princeton University
contact email	icristea@princeton.edu
lab head
Tim Howard
contact affiliation	Princeton University
contact email	th12@princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD025101

PRIDE project URI

• PRIDE
  1. PXD025101
     1. Label: PRIDE project
     2. Name: Contribution of IFIX to nuclear and cytoplasmic proteome changes during immune signaling