PXD024910 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative proteomics analysis reveals novel insights into mechanisms of action of Disulfiram (DSF) |
Description | The new uses of the old drugs may reduce cost and shortens the production cycle of research and development, especially that approved by FDA for important clinical conditions. Alcohol abuse Disulfiram (DSF) has been proven safe and shows the promising anti-tumor effect in may preclinical studies. However, the potential side effects of DSF on tumor remain unknown. In this study, we explored the role of DSF in cancer cells and searched for the differential expressed protein after DSF treatment in the HeLa cells. To fully understand the mechanism of action of DSF with a systems perspective, we employed a quantitative proteomics strategy to systematically identify potential targets of DSF. In total, 201 proteins were dys-regulated significantly after DSF exposure, implying that they may be potential targets of DSF. Analysis of this data on a system level revealed major changes of proteins involved in diverse biological processes, including metabolic process and response to stimulus. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-27 |
AnnouncementXML | Submission_2021-11-27_00:18:42.358.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | peng zheng |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | 6x(13)C labeled residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-22 04:36:34 | ID requested | |
⏵ 1 | 2021-11-27 00:18:43 | announced | |
Publication List
Zheng P, Liu C, Wu Y, Xu R, Chen Y, Hu F, Chen Z, Zhang T, Quantitative proteomics analysis reveals novel insights into mechanisms of action of disulfiram (DSF). Proteomics Clin Appl, 16(1):e2100031(2022) [pubmed] |
Keyword List
submitter keyword: DSF |
quantitative proteomics |
migration |
invasion; |
Contact List
peng zheng |
contact affiliation | Institute of Biology and Medicine, College of Life Science and Healthy, Wuhan University of Science and Technology, Wuhan, China, |
contact email | pengzh1984@wust.edu.cn |
lab head | |
peng zheng |
contact affiliation | Wuhan university of science and technology |
contact email | pengzh1984@wust.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD024910 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024910
- Label: PRIDE project
- Name: Quantitative proteomics analysis reveals novel insights into mechanisms of action of Disulfiram (DSF)