PXD024837-1

PXD024837 is an original dataset announced via ProteomeXchange.

Title	The HLA-Ligand-Atlas. DIA-SWATH Data
Description	The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this repository, we extend the the HLA-Ligand-Atlas, a comprehensive map of HLA-I and HLA-II-presented peptides from 30 benign tissues, 51 HLA-I alleles, and 86 HLA-II alleleswith matching DIA-SWATH measurements. Due to the scarcity of benign human samples, the tissue was extracted from different organs at autopsy from human subjects without any diagnosed malignancy. This dataset holds great promise in answering both basic and translational questions in fields such as autoimmunity, organ/tissue transplantation, and cancer immunotherapy.
HostingRepository	PRIDE
AnnounceDate	2025-09-05
AnnouncementXML	Submission_2025-09-05_04:59:42.164.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ana Marcu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-18 07:39:50	ID requested
⏵ 1	2025-09-05 04:59:42	announced

10.1136/JITC-2025-012083;

submitter keyword: Human, HLA, DIA, SWATH, Immunopeptidomics

Hans-Georg Rammensee
contact affiliation	Institute for Cell Biology, Dept. Immunology Auf der Morgenstelle 15, 72076 Tübingen, Germany Partner Site of the German Cancer Consortium
contact email	rammensee@uni-tuebingen.de
lab head
Ana Marcu
contact affiliation	University of Tübingen, Interfaculty Institute for Cell Biology, Department of Immunology
contact email	anamarcu.pe@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD024837

PRIDE project URI

• PRIDE
  1. PXD024837
     1. Label: PRIDE project
     2. Name: The HLA-Ligand-Atlas. DIA-SWATH Data