PXD024829-2

PXD024829 is an original dataset announced via ProteomeXchange.

Title	The proteome and phosphoproteome of acute stress in the mouse hippocampus
Description	The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, little is known about the nature and dynamics of the underlying molecular cascades. We used a brief forced swim exposure to trigger a strong stress response in mice, which transiently increases anxiety, but does not lead to lasting maladaptive behavioral changes. Using multiomic profiling we characterize the stress-induced molecular events in the hippocampus over time, across molecular scales, and down to the level of cell types and single cells. Our results unveil the complexity and specificity of the healthy stress response, with widespread changes in protein phosphorylation and gene transcription, but tightly regulated protein translation. All observed molecular events resolve efficiently within 4 hours after initiation of stress.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:31:10.877.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lukas von Ziegler
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-18 03:47:59	ID requested
1	2022-02-09 05:47:42	announced
⏵ 2	2024-10-22 05:31:11	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: mouse, hippocampus, phosphoproteome, acute stress, proteome

Johannes Bohacek
contact affiliation	Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Switzerland
contact email	johannes.bohacek@hest.ethz.ch
lab head
Lukas von Ziegler
contact affiliation	Swiss Federal Institute of Technology
contact email	lukasvonziegler@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024829
     1. Label: PRIDE project
     2. Name: The proteome and phosphoproteome of acute stress in the mouse hippocampus