PXD024777-1

PXD024777 is an original dataset announced via ProteomeXchange.

Title	Proteome landscape of mouse oocyte mitochondria
Description	Mitochondria are essential organelles that provide energy for mammalian cells, with multiple functions such as signal transduction, cellular differentiation, and regulation of apoptosis. Compared with the mitochondria in somatic cells, oocyte mitochondria have an additional layer of importance since they are required for germ cell maturation, dysfunctions of which can lead to severe inherited disorders. Thus, a systematic proteomic profile of oocyte mitochondria is urgently needed for basic and clinical research, but has been hindered by the rarity of oocyte samples and technical challenges associated with capturing mitochondrial proteins from live oocytes. Here, in this work, using proximity labeling proteomics, we established a mitochondria-specific ascorbate peroxidase (APEX2) reaction in live GV staged oocytes of mouse and and explore oocyte mitochondrial proteomics.
HostingRepository	iProX
AnnounceDate	2021-03-16
AnnouncementXML	Submission_2021-06-30_23:26:12.024.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Na Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-16 21:04:41	ID requested
⏵ 1	2021-06-30 23:26:12	announced
2	2023-02-19 23:36:29	announced	2023-02-20: Update publication information.

Dataset with its publication pending

submitter keyword: Oocyte, mitochondria

Mo Li
contact affiliation	Peking University Third Hospita
contact email	limo@hsc.pku.edu.cn
lab head
Na Zhang
contact affiliation	Peking University Third Hospital
contact email	zhangna9902@163.com
dataset submitter

iProX dataset URI