PXD024744-1

PXD024744 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of Caenorhabditis elegans wound model reveals novel molecular players involved in repair
Description	Now a days, wound healing is becoming a global threat that impact economy of the country severely. Though the steps involved in wound healing are well characterised, direct therapeutics for the accelerated wound healing is comparatively less. This is solely because of the incomplete mechanism of healing and the lack of knowledge on molecular players involved in wound healing. Hence, in the present study, we have investigated the molecular players involved in wound healing process using a versatile model organism Caenorhabditis elegans through proteomic analyses. Especially, we have employed the high through put proteomic analyses tools such as 2-D GE and LCMS/MS analysis to uncover the molecular players involved in wound healing. As a result of LC-MS/MS analysis at 0 and 24 h, a total of 435 proteins were regulated in both unwounded and wounded conditions in which 13 and 10 proteins were significantly differential regulated. Bioinformatics analyses result suggested that molecular players involved in cortical actin cytoskeleton organization, protein phosphatase binding, and proton transporting ATP synthase activity were identified at 0 h; skeletal muscle myosin thick filament assembly, actin filament depolymerization were identified at 24 h.
HostingRepository	PRIDE
AnnounceDate	2021-04-16
AnnouncementXML	Submission_2021-04-15_21:54:42.537.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Krishnaswamy Balamurugan
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	iodoacetamide derivatized residue
Instrument	6545 Q-TOF LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-15 08:23:19	ID requested
⏵ 1	2021-04-15 21:54:43	announced

Pooranachithra M, Satheesh Kumar C, Bhaskar JP, Venkateswaran K, Ravichandiran V, Balamurugan K, Proteomic analysis of Caenorhabditis elegans wound model reveals novel molecular players involved in repair. J Proteomics, 240():104222(2021) [pubmed]

submitter keyword: C.elegans, Whole body, Injury, LCMS/MS

Dr. KB Lab (Host Pathogen Interaction Lab)
contact affiliation	Professor, Department of Biotechnology, Alagappa University, Karaikudi
contact email	bsuryar@yahoo.com
lab head
Krishnaswamy Balamurugan
contact affiliation	Alagappa University
contact email	bsuryar@yahoo.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024744
     1. Label: PRIDE project
     2. Name: Proteomic analysis of Caenorhabditis elegans wound model reveals novel molecular players involved in repair