PXD024728-1

PXD024728 is an original dataset announced via ProteomeXchange.

Title	SOD1 is a possible predictor of COVID-19 progression as revealed by plasma proteomics
Description	The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide health emergency. Patients infected with SARS-CoV-2 present with diverse symptoms relating to the severity of the disease. Determining the proteomic changes associated with these diverse symptoms and in different stages of infection is beneficial for clinical diagnosis and management. Here, we performed a Tandem Mass Tag (TMT)-labeling proteomic study on the plasma of healthy controls and COVID-19 patients, including those with asymptomatic infection (NS), mild syndrome (MS), and severe syndrome in the early phase (SSEP) and the later phase (SSLP). While the number of patients included in each group is low, our comparative proteomic analysis revealed that complement and coagulation cascades, cholesterol metabolism and glycolysis-related proteins were affected after infection with SARS-CoV-2. Compared to healthy controls, ELISA analysis confirmed that SOD1, PRDX2 and LDHA levels were increased in the patients with severe symptoms. Both gene set enrichment analysis and receiver operator characteristic analysis indicated that SOD1 could be a pivotal indicator for the severity of COVID-19. Our results indicated that plasma proteome changes differed based on symptoms and disease stages and SOD1 could be a predictor protein for indicating COVID-19 progression. These results may also provide new understanding for COVID-19 diagnosis and treatment.
HostingRepository	PRIDE
AnnounceDate	2021-07-05
AnnouncementXML	Submission_2021-07-05_03:53:22.416.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024728
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Benhong Xu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-15 02:32:48	ID requested
⏵ 1	2021-07-05 03:53:22	announced

Dataset with its publication pending

ProteomeXchange project tag: Covid-19

submitter keyword: plasma,covid-19,TMT,SOD1

Benhong Xu
contact affiliation	Shenzhen Center for Disease Control and Prevention
contact email	xubenhong@szcdc.net
lab head
Benhong Xu
contact affiliation	Shenzhen Center for Disease Control and Prevention
contact email	xubenhong@szcdc.net
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024728
     1. Label: PRIDE project
     2. Name: SOD1 is a possible predictor of COVID-19 progression as revealed by plasma proteomics