PXD024724 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy |
Description | There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying molecular events that cause these abnormal protein accumulations remain unclear. Here, we hypothesized that identifying human brain proteome from serial CTE stages (CTE I-IV) would provide critical new insights into CTE pathogenesis. Brain samples from frontotemporal lobar degeneration due to microtubule associated protein tau (FTLD-MAPT) mutations were also included as a distinct tauopathy phenotype for comparison. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-17 |
AnnouncementXML | Submission_2022-02-16_23:51:54.368.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Duc Duong |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-15 00:40:43 | ID requested | |
⏵ 1 | 2022-02-16 23:51:55 | announced | |
Publication List
Gutierrez-Quiceno L, Dammer EB, Johnson AG, Webster JA, Shah R, Duong D, Yin L, Seyfried NT, Alvarez VE, Stein TD, McKee AC, Hales CM, A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy. Mol Neurodegener, 16(1):40(2021) [pubmed] |
Keyword List
submitter keyword: CTE, TMT, WGCNA |
Contact List
Chadwick Hales, MD, PhD |
contact affiliation | Assistant Professor Department of Neurology |
contact email | cmhales@emory.edu |
lab head | |
Duc Duong |
contact affiliation | Center of Neurodegenerative Diseases |
contact email | dduong@emory.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD024724 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024724
- Label: PRIDE project
- Name: A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy