PXD024658 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics investigation of the time course responses of RAW264.7 macrophages to infections with the wild-type and twin-arginine translocation mutant strains of Brucella melitensis |
Description | Brucella, a notorious intracellular pathogen, causes chronic infections in many mammals, including humans. The twin-arginine translocation (Tat) pathway transports folded proteins across the cytoplasmic membrane; protein substrates translocated by Brucella include ABC transporters, oxidoreductases, and cell envelope biosynthesis proteins. Previously, we showed that a Tat mutant of Brucella melitensis M28 exhibits reduced survival within murine macrophages. In this study, we compared the host responses elicited by wild-type M28 and its Tat-mutant strains ex vivo. We utilized label-free quantitative proteomics to assess proteomic changes in RAW264.7 macrophages after infection with M28 and its Tat mutants. |
HostingRepository | PRIDE |
AnnounceDate | 2021-07-05 |
AnnouncementXML | Submission_2021-07-04_21:54:49.088.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xin Yan |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-11 02:19:32 | ID requested | |
⏵ 1 | 2021-07-04 21:54:49 | announced | |
Publication List
Yan X, Hu S, Yang Y, Xu D, Liu W, Li G, Cai W, Bu Z, . Front Cell Infect Microbiol, 11():679571(2021) [pubmed] |
Keyword List
submitter keyword: Brucella melitensis |
twin-arginine protein translocation |
immune response |
RAW264.7 cell model |
Contact List
Xin Yan |
contact affiliation | Harbin Veterinary Research Institute |
contact email | ElijahY92@163.com |
lab head | |
Xin Yan |
contact affiliation | Harbin Veterinary Research Institute |
contact email | ElijahY92@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/07/PXD024658 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024658
- Label: PRIDE project
- Name: Proteomics investigation of the time course responses of RAW264.7 macrophages to infections with the wild-type and twin-arginine translocation mutant strains of Brucella melitensis