PXD024638-1

PXD024638 is an original dataset announced via ProteomeXchange.

Title	Venom proteomic analysis of two medically important Nigerian viperidae (Echis ocellatus and Bitis arietans) snake species
Description	Hydrophilic interaction liquid chromatography coupled with LC- MS/MS was used to analyze the crude venom extracts of Echis ocellatus (Carpet viper) and Bitis arietans (Puff adder). The gel-free proteomic analysis of the crude venom extracts from E. ocellatus and B. arietans yielded the identification of 86 and 80 proteins, respectively. Seventy- nine proteins were common between the two snake species with a 90.8% similarity. The identified proteins belong to 12 protein families where serine proteases (22.31%) and metalloproteinases (21.06%) were the dominant proteins in the venom of B. arietans. Metalloproteinases (34.84%), phospholipase A 2 s (25.69%) and serine proteases (17.25%) represents the major toxins in the E. ocellatus venom. This study provides some valuable insights into the toxin families to be neutralized in case of envenomation.
HostingRepository	PRIDE
AnnounceDate	2021-03-11
AnnouncementXML	Submission_2021-03-10_21:50:56.451.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024638
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Emeka Dingwoke
SpeciesList	scientific name: Bitis arietans; NCBI TaxID: 8692; scientific name: Echis ocellatus; NCBI TaxID: 99586;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-10 03:25:31	ID requested
⏵ 1	2021-03-10 21:50:56	announced

Dataset with its publication pending

submitter keyword: Snakebite, neglected tropical disease, viperidae, Bitis arietans, Echi ocellatus, snake venom, proteomic, mass spectrometry.

Emeka John Dingwoke
contact affiliation	Department of Biochemistry/Venom, Antivenom and Natural Toxins Research Centre, Ahmadu Bello University, Zaria
contact email	dinhimself@yahoo.com
lab head
Emeka Dingwoke
contact affiliation	Department of Biochemistry Venom, Antivenom and Natural Toxins Research Centre, Ahmadu Bello University, Zaria, Nigeria.
contact email	dinhimself@yahoo.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD024638

PRIDE project URI

• PRIDE
  1. PXD024638
     1. Label: PRIDE project
     2. Name: Venom proteomic analysis of two medically important Nigerian viperidae (Echis ocellatus and Bitis arietans) snake species