PXD024625-1

PXD024625 is an original dataset announced via ProteomeXchange.

Title	The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder
Description	We identified that peroxins were still expressed in Zellweger Spectrum Disorder (ZSD) and a subset of them accumulated on the mitochondrial membrane, which resulted in gross mitochondrial abnormalities and impaired mitochondrial metabolic function. In this complexome analysis we detected several peroxins in the mitochondrial fraction in the absence of functional peroxisomes and that this accumulation is exacerbated by the loss of the mitochondrial extractase Msp1. In addition, we observed that specific peroxisomal matrix proteins localize to the mitochondria, which suggest that a functional peroxisomal docking and import complex assembles on the mitochondria in the absence of peroxisomes.
HostingRepository	PRIDE
AnnounceDate	2021-06-25
AnnouncementXML	Submission_2021-06-25_00:42:14.844.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilka Wittig
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-10 00:05:37	ID requested
⏵ 1	2021-06-25 00:42:15	announced

Dataset with its publication pending

submitter keyword: LC-MSMS, complexome profiling, mitochondria, peroxisomes, peroxisomal biogenesis disorder, peroxisomal import, mitocondrial quality control

Jared Rutter
contact affiliation	Medical School, Department of Biochemistry, University of Utah, Salt Lake City, USA
contact email	rutter@biochem.utah.edu
lab head
Ilka Wittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD024625

PRIDE project URI

• PRIDE
  1. PXD024625
     1. Label: PRIDE project
     2. Name: The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder