PXD024531-1

PXD024531 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability
Description	we generated nuclear and cytoplasmic extracts from FLAG-LARP4 cells, purified LARP4, using FLAG affinity resin, and analyzed the purified complexes, using mass spectrometry. Consistent with previous reports, LARP4 is primarily, but not exclusively, cytoplasmic, and we could robustly detect associated proteins involved in poly(A)-binding. Surprisingly, we also detected numerous components of the cleavage and polyadenylation machinery associated with LARP4, suggesting a potential direct role in APA regulation
HostingRepository	MassIVE
AnnounceDate	2021-03-08
AnnouncementXML	Submission_2021-03-08_12:39:43.983.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Bill Russell
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion ETD

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-04 15:59:19	ID requested
⏵ 1	2021-03-08 12:39:44	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Poly(A), APMS, LCMS

submitter keyword: Poly(A), APMS, LCMS

Contact List

William Russell
contact affiliation	UTMB
contact email	bill.russell@utmb.edu
lab head
Bill Russell
contact affiliation	UTMB
contact email	bill.russell@utmb.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000087000/