PXD024410-3
PXD024410 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Distinct Molecular Signature of Asymptomatic COVID-19 Revealed by Lipidomic Characterization |
| Description | Asymptomatic infection has become one of the biggest challenges in controlling the spread of COVID-19. However, the rapid diagnosis and pathogenesis elucidation of the disease remain critical issues. Here, we performed comprehensive lipidomic profiling of 267 serum samples from 89 asymptomatic COVID-19 patients and 178 healthy controls. A panel of 15 key lipids was discovered that could high-efficiently distinguish asymptomatic patients by using a new ensemble learning model, which provided a high accuracy of 96.0% with only 3.6% false positive rate and 4.8% false negative rate. In addition, characteristic lipidomic changes revealed distinct dysregulated lipid metabolism upon asymptomatic SARS-CoV-2 infection, which implicated the specific host immune, inflammatory, and antiviral responses during the virus invasion in asymptomatic COVID-19. This study provides an effective method for the pre-diagnosis of asymptomatic COVID-19, and the revealed molecular signature provided clues for the pathogenesis and therapy of this disease. |
| HostingRepository | iProX |
| AnnounceDate | 2022-06-14 |
| AnnouncementXML | Submission_2023-02-20_19:17:40.204.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Suming Chen |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-02-28 20:54:08 | ID requested | |
| 1 | 2021-02-28 20:54:46 | announced | |
| 2 | 2022-06-13 20:44:38 | announced | 2022-06-14: Update informaiton. |
| ⏵ 3 | 2023-02-20 19:17:41 | announced | 2022-06-14: Update informaiton. 2023-02-21: Update information. |
Publication List
| Chen M, Hao Y, Chen S, A protocol for investigating lipidomic dysregulation and discovering lipid biomarkers from human serums. STAR Protoc, 3(1):101125(2022) [pubmed] |
Keyword List
| submitter keyword: COVID-19, Asymptomatic, Lipidomics |
Contact List
| Suming Chen | |
|---|---|
| contact affiliation | The Institute for Advanced Studies, Wuhan University |
| contact email | chensm@iccas.ac.cn |
| lab head | |
| Suming Chen | |
| contact affiliation | The Institute for Advanced Studies, Wuhan University |
| contact email | chensm@iccas.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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