PXD024346-1

PXD024346 is an original dataset announced via ProteomeXchange.

Title	Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy)
Description	Recent improvements in the analysis ancient biomolecules from human remains and associated dental calculus have provided new insights into the prehistoric diet and past genetic diversity of our species. Here we present a “multi-omics” study, integrating genomic and proteomic analyses of two post-Last Glacial Maximum (LGM) individuals from San Teodoro cave (Italy), to reconstruct their lifestyle and the post-LGM resettlement of Europe. Our analyses show genetic homogeneity in Sicily during the Palaeolithic, representing a hitherto unknown Italian genetic lineage within the previously identified “Villabruna cluster”. We argue that this lineage took refuge in Italy during the LGM, followed by a subsequent spread to central-western Europe. Analyses of dental calculus using genomics and proteomics showed a similar oral microbiome composition as Neandertals, but distinct from later foragers and farmers, revealing also a diet based on mammals, fish and plants. Our results demonstrate the power of using a multi-omics approach in the study of prehistoric human populations.
HostingRepository	PRIDE
AnnounceDate	2022-10-27
AnnouncementXML	Submission_2022-10-27_02:58:27.137.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	MeaghanMackie
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-24 02:18:38	ID requested
⏵ 1	2022-10-27 02:58:27	announced

Dataset with its publication pending

submitter keyword: dental calculus, bone, Human, Sicily, Italy, archaeology, LC-MS/MS

EnricoCappellini
contact affiliation	The Globe Institue, University of Copenhagen
contact email	ecappellini@sund.ku.dk
lab head
MeaghanMackie
contact affiliation	University of Copenhagen
contact email	meaghan@palaeome.org
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024346
     1. Label: PRIDE project
     2. Name: Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy)