PXD024304 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic and pathway profiling of four Breast Cancer cell lines. |
Description | Biomarker discovery in breast cancer (BC) is a clinical need for therapeutics and non-invasive diagnostics. In a single study, we provide a comparative differential proteomic profile of four invasion, metastasis, angiogenesis and drug resistance. Exosome proteome profile reflects their different BC cell origin suggesting potential indicators of BC subtype. Further, our pathway inference analysis reveals a differential role of exosomes in BC signalling pathways in recipient cells, according to their protein cargo and cell origin. Our results may significantly contribute to further studies for the design of BC biomarker predictor to stratify BC patients and the development of novel therapeutic strategies.BC cell lines and their derived- exosomes, representative of the most relevant BC subtypes in clinic. Differentially-expressed proteins, in both cells and exosomes, include indicators of |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_02:51:37.980.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Luz Valero |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-02-22 06:34:52 | ID requested | |
⏵ 1 | 2024-10-17 02:51:38 | announced | |
Publication List
10.1007/s00018-024-05403-z; |
Andreu Z, Hidalgo MR, Masi, á E, Romera-Giner S, Malmierca-Merlo P, L, ó, pez-Guerrero JA, Garc, í, a-Garc, í, a F, Vicent MJ, Comparative profiling of whole-cell and exosome samples reveals protein signatures that stratify breast cancer subtypes. Cell Mol Life Sci, 81(1):363(2024) [pubmed] |
Keyword List
submitter keyword: Biomarker discovery, breast cancer, exosomes, Differentially-expressed proteins, proteomic profile |
Contact List
María Jesús Vicent, Francisco García García |
contact affiliation | Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, 46012 Valencia, Spain |
contact email | fgarcia@cipf.es |
lab head | |
Luz Valero |
contact affiliation | Universitat de Valencia |
contact email | mluz.valero@uv.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD024304 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024304
- Label: PRIDE project
- Name: Proteomic and pathway profiling of four Breast Cancer cell lines.