PXD024284 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Reduced thrombogenicity of surface-treated Nitinol implants steered by altered protein adsorption |
Description | Blood-contacting medical implants made of Nitinol and other titanium alloys, such as neurovascular flow diverters and peripheral stents, have the disadvantage of being highly thrombogenic. This makes the use of systemic (dual) anti platelet / anticoagulant therapies inevitable with related risks of device thrombosis, bleeding and other complications. Meeting the urgent clinical demand for a less thrombogenic Nitinol surface, we describe here a treatment of standard, commercially available Nitinol that renders its surface ultra-hydrophilic and functionalized with phosphate ions. The efficacy of this treatment was assessed by comparing standard and surface-treated Nitinol disks and braids, equivalent to flow diverters. Static and dynamic (Chandler loop) blood incubation tests showed a drastic reduction of thrombus formation on treated devices. Surface chemistry and proteomic analysis indicated a key role of phosphate and calcium ions in steering blood protein adsorption and avoiding coagulation cascade activation and platelet adhesion. A good endothelialization of the surface confirmed the biocompatibility of the treated surface. |
HostingRepository | PRIDE |
AnnounceDate | 2022-01-21 |
AnnouncementXML | Submission_2022-01-21_06:56:07.988.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Katharina Gegenschatz |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-02-22 01:44:15 | ID requested | |
⏵ 1 | 2022-01-21 06:56:08 | announced | |
2 | 2022-01-24 05:55:28 | announced | 2022-01-24: Updated publication reference for PubMed record(s): 34673227. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Antithrombogenic treatment, hemocompatibility, cardiovascular devices, intrinsic coagulation pathway, platelet adhesion, proteomics |
Contact List
Martin Ehrbar |
contact affiliation | Head of Research Department of Obstetrics University Hospital Zurich Schmelzbergstrasse 12 PATH G48 / PF 125 CH-8091 Zürich Switzerland |
contact email | martin.ehrbar@usz.ch |
lab head | |
Katharina Gegenschatz |
contact affiliation | University Hospital Zurich |
contact email | katharina.gegenschatz@usz.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024284
- Label: PRIDE project
- Name: Reduced thrombogenicity of surface-treated Nitinol implants steered by altered protein adsorption