PXD024150 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of triple negative mouse breast cancer isografts after electro-hyperthermia treatment |
Description | Modulated electro-hyperthermia (mEHT) is a selective cancer treatment used in human oncology complementing other therapies. During mEHT, a focused electromagnetic field (EMF) is generated within the tumor, by elevated oxidative glycolysis (Warburg effect) and conductivity of the tumor. The EMF induce cell death by thermal and non-thermal effects. Here we investigated an aggressive, therapy resistant triple negative breast cancer (TNBC) model. 4T1/4T07 isografts inoculated orthotopically into female BALB/c mice were treated with mEHT 3-5 times. mEHT induced the upregulation of the stress related Hsp70 and cleaved caspase-3 proteins, resulting in effective inhibition of tumor growth and proliferation. |
HostingRepository | PRIDE |
AnnounceDate | 2021-04-14 |
AnnouncementXML | Submission_2021-04-13_22:54:37.329.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD024150 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Marko Fonovic |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-02-11 22:57:00 | ID requested | |
⏵ 1 | 2021-04-13 22:54:37 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Orbitrap, proteomics, breast cancer, stress response |
Contact List
prof. dr. Marko Fonović |
contact affiliation | Department of Biochemistry and Molecular and Structural Biology, Jozef Stefen Institute, Jamova cesta 39, 1000, Ljubljana, Slovenia |
contact email | marko.fonovic@ijs.si |
lab head | |
Marko Fonovic |
contact affiliation | Jozef Stefan Institute |
contact email | marko.fonovic@ijs.si |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD024150 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024150
- Label: PRIDE project
- Name: Proteomic analysis of triple negative mouse breast cancer isografts after electro-hyperthermia treatment