PXD024107-1
PXD024107 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1 |
Description | Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy and is caused by an repeat expansion [r(CUG)exp] located in the 3' untranslated region of the DMPK gene. Symptoms include skeletal and cardiac muscle dysfunction and fibrosis. In DM1, there is a lack of established biomarkers in routine clinical practice. Thus, we aimed to identify a blood biomarker with relevance for DM1-pathophysiology and clinical presentation. |
HostingRepository | PRIDE |
AnnounceDate | 2023-05-02 |
AnnouncementXML | Submission_2023-05-02_05:45:27.369.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | LaxmikanthKollipara |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-02-10 03:10:12 | ID requested | |
⏵ 1 | 2023-05-02 05:45:28 | announced | |
2 | 2023-11-14 08:45:32 | announced | 2023-11-14: Updated project metadata. |
Publication List
Nguyen CDL, Jimenez-Moreno AC, Merker M, Bowers CJ, Nikolenko N, Hentschel A, M, ü, ntefering T, Isham A, Ruck T, Vorgerd M, Dobelmann V, Gourdon G, Schara-Schmidt U, Gangfuss A, Schr, ö, der C, Sickmann A, Gross C, Gorman G, Stenzel W, Kollipara L, Hathazi D, Spendiff S, Gagnon C, Preusse C, Duchesne E, Lochm, ü, ller H, Roos A, Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1. J Neurol, 270(6):3138-3158(2023) [pubmed] |
Keyword List
submitter keyword: DM1 biomarker, DMSXL,DMPK, clinical proteomics, CTG-trinucleotide expansion, Steinert’s disease |
Contact List
Prof. Dr. AlbertSickmann | |
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contact affiliation | Prof. Dr. Albert Sickmann President Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Otto-Hahn-Straße 6b 44227 Dortmund, Germany P: +49 (0)2 31.13 92-100 F: +49 (0)2 31.13 92-200 albert.sickmann@isas.de www.isas.de twitter.com/isas_Leibniz |
contact email | albert.sickmann@isas.de |
lab head | |
LaxmikanthKollipara | |
contact affiliation | Leibniz – Institut für Analytische Wissenschaften - ISAS - e.V. |
contact email | laxmikanth.kollipara@isas.de |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD024107 |
PRIDE project URI |
Repository Record List
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