PXD024087 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Kinome and phosphoproteome reprogramming underlie the immunological abnormalities in severe COVID-19 |
Description | The SARS-CoV-2 infection elicits widespread immunological reactions and causes severe diseases in some individuals. However, the molecular basis behind the excessive, yet non-productive immune response in COVID-19 patients with severe diseases is not fully understood. Nor is it fully known of the molecular and cellular discrepancies between severe COVID-19 and sepsis caused by other infections. To gain systems-level insights into the pathogenesis of COVID-19, we compared the blood proteome and phosphoproteome of patients under intensive care with or without SARS-CoV-2 infection, and healthy control subjects by quantitative mass spectrometry. SARS-CoV-2 infection causes global reprogramming of the kinome and the phosphoproteome, resulting in incomplete adaptive immune responses mediated by B cells and T cells, compromised innate immune response via inhibitory SIGLEC and SLAM family receptor signaling, and excessive JAK/STAT signaling. Our work identifies the kinases CK2, SYK, JAK2/3, TYK2, and the cytokine IL-12 as potential targets for the immunomodulatory treatment of severe COVID-19 and provides a valuable resource for deciphering the mechanism of pathogen-host interactions. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-24 |
AnnouncementXML | Submission_2024-05-24_03:21:30.301.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tomonori Kaneko |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-02-09 08:57:42 | ID requested | |
⏵ 1 | 2024-05-24 03:21:31 | announced | |
Publication List
10.1186/s12014-024-09457-w; |
Kaneko T, Ezra S, Abdo R, Voss C, Zhong S, Liu X, Hovey O, Slessarev M, Van Nynatten LR, Ye M, Fraser DD, Li SS, Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients. Clin Proteomics, 21(1):13(2024) [pubmed] |
Keyword List
submitter keyword: T cell, immune regulation, phosphoproteome, inhibitory receptor, CK2, SARS-CoV-2, IL-12, SYK,COVID-19, cytokine, natural killer cells, immunoreceptor Tyr-based motifs, signal transduction, B cell, kinase, JAK-STAT, proteome |
Contact List
Shawn SC Li |
contact affiliation | Department of Biochemistry, Western University, Canada |
contact email | sli@uwo.ca |
lab head | |
Tomonori Kaneko |
contact affiliation | Western University |
contact email | tkaneko@uwo.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024087
- Label: PRIDE project
- Name: Kinome and phosphoproteome reprogramming underlie the immunological abnormalities in severe COVID-19