PXD024060-1

PXD024060 is an original dataset announced via ProteomeXchange.

Title	Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in IBD
Description	The goal of this project is to find out whether human intestinal IgA1 and IgA2 secretion, transport and reactivity towards the microbiota might be involved in dysbiosis induction during Crohn’s disease and Ulcerative colitis. Mass spectrometry was used to characterize SIgA from Crohn’s disease patient and Ulcerative colitis patient, in term of O- and N-glycosylation in order to study their reverse transcytosis capacity and their role in intestinal inflammation.
HostingRepository	PRIDE
AnnounceDate	2022-06-27
AnnouncementXML	Submission_2022-06-27_15:45:47.322.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Katell Bathany
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; complex glycosylation; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-08 08:06:59	ID requested
⏵ 1	2022-06-27 15:45:47	announced

Dataset with its publication pending

submitter keyword: intestinal disease, immune mucosal response, IgA modifications, glycosylations

Caroline TOKARSKI
contact affiliation	CBMN UMR5248 CNRS-Univ. Bordeaux
contact email	c.tokarski@cbmn.u-bordeaux.fr
lab head
Katell Bathany
contact affiliation	University of Bordeaux
contact email	k.bathany@cbmn.u-bordeaux.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD024060

PRIDE project URI

• PRIDE
  1. PXD024060
     1. Label: PRIDE project
     2. Name: Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in IBD