PXD023957-1

PXD023957 is an original dataset announced via ProteomeXchange.

Title	The phosphorylation of the Smad2/3 linker region by Nemo-like kinase regulates TGF-β signaling
Description	Smad2 and Smad3 (Smad2/3) primarily mediates the transforming growth factor-β (TGF-β) signaling that drives cell proliferation, differentiation, and migration. The dynamics of the Smad2/3 phosphorylation provides the key mechanism for regulating the TGF-β signaling pathway. Here we identified NLK as a novel regulator of TGF-β signaling pathway via modulating the phosphorylation of Smad2/3 in the linker region.
HostingRepository	PRIDE
AnnounceDate	2021-09-10
AnnouncementXML	Submission_2021-09-10_00:17:03.793.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanchi Zhou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-03 01:55:48	ID requested
⏵ 1	2021-09-10 00:17:04	announced

Liang J, Zhou Y, Zhang N, Wang D, Cheng X, Li K, Huang R, Lu Y, Wang H, Han D, Wu W, Han M, Miao S, Wang L, Zhao H, Song W, signaling. J Biol Chem, 296():100512(2021) [pubmed]

submitter keyword: NLK, Smad2, Smad3, phosphorylation

Wei Song
contact affiliation	State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China
contact email	songwei@ibms.pumc.edu.cn
lab head
Yanchi Zhou
contact affiliation	Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China
contact email	zhouyc27@126.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023957
     1. Label: PRIDE project
     2. Name: The phosphorylation of the Smad2/3 linker region by Nemo-like kinase regulates TGF-β signaling