PXD023954 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Chicken MHC class II presented Marek's disease virus (MDV) and infectious bursal disease virus (IBDV) antigenic peptides |
Description | Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens. Unlike humans and other typical mammals, the major histocompatibility complex (MHC) of chickens can confer decisive resistance or susceptibility to many viruses. Examples are Marek's disease virus (MDV) and Infectious bursal disease virus (IBDV). We used a new in vitro infection system and immunopeptidomics to identify peptides presented to T lymphocytes via classical MHC class II molecules. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-10 |
AnnouncementXML | Submission_2021-09-10_00:25:56.911.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michael Ghosh |
SpeciesList | scientific name: Gallus gallus (Chicken); NCBI TaxID: 9031; |
ModificationList | monohydroxylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-02-03 01:55:32 | ID requested | |
⏵ 1 | 2021-09-10 00:25:57 | announced | |
Publication List
Halabi S, Ghosh M, Stevanovi, ć S, Rammensee HG, Bertzbach LD, Kaufer BB, Moncrieffe MC, Kaspers B, H, ä, rtle S, Kaufman J, The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif. PLoS Biol, 19(4):e3001057(2021) [pubmed] |
Keyword List
submitter keyword: Chicken MHC, MHC class I, MHC class II, MDV, IBDV, immunopeptidomics |
Contact List
Stefan Stevanovic |
contact affiliation | Department of Immunology, Interfaculty Institute for Cell Biology, Tübingen, Germany |
contact email | stefan.stevanovic@uni-tuebingen.de |
lab head | |
Michael Ghosh |
contact affiliation | Department of Immunology, Tübingen |
contact email | Michaelghosh@gmx.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023954
- Label: PRIDE project
- Name: Chicken MHC class II presented Marek's disease virus (MDV) and infectious bursal disease virus (IBDV) antigenic peptides