PXD023909-1

PXD023909 is an original dataset announced via ProteomeXchange.

Title	Exosomal Proteins and Brown Fat Activation
Description	Brown adipose tissue (BAT) is a promising weapon to combat obesity and metabolic disease. BAT is thermogenic and consumes substantial amounts of glucose and fatty acids as fuel for thermogenesis and energy expenditure. To study BAT function in large human longitudinal cohorts, safe and precise detection methodologies are needed. Although regarded a gold standard, the foray of PET-CT into BAT research and clinical applications is limited by its high ionizing radiation doses. Here, we show that brown adipocytes release exosomes in blood plasma which can be utilized to assess BAT activity. In this study, we investigated circulating protein biomarkers that can accurately and reliably reflect BAT activation triggered by cold exposure, capsinoids ingestion and thyroid hormone excess in humans.
HostingRepository	PRIDE
AnnounceDate	2022-06-09
AnnouncementXML	Submission_2022-06-09_04:00:31.113.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Narasimhan Kothandaraman
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-31 23:14:33	ID requested
⏵ 1	2022-06-09 04:00:31	announced

Leow MK, Rengaraj A, Narasimhan K, Verma SK, Yaligar J, Thu GLT, Sun L, Goh HJ, Govindharajulu P, Sadananthan SA, Michael N, Meng W, Gallart-Palau X, Sun L, Karnani N, Sze NSK, Velan SS, Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L). Biosci Rep, 42(5):(2022) [pubmed]

submitter keyword: Exosomes, Brown Fat, Biomarkers

Melvin Khee Shing Leow
contact affiliation	1Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore 2 Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore 3 Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore 4Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 5 Department of Endocrinology, Tan Tock Seng Hospital (TTSH), Singapore
contact email	melvin_leow@sics.a-star.edu.sg
lab head
Narasimhan Kothandaraman
contact affiliation	Singapore Insitute of Clinical Sciences
contact email	Kothandaraman_Narasimhan@sics.a-star.edu.sg
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD023909

PRIDE project URI

• PRIDE
  1. PXD023909
     1. Label: PRIDE project
     2. Name: Exosomal Proteins and Brown Fat Activation