PXD023885-1

PXD023885 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of growth cones from WT and HD mice
Description	Although Huntington’s disease (HD) is a late onset neurological condition, studies suggest a developmental contribution to its adult manifestations. Imaging studies in presymptomatic HD gene carriers revealed early alterations in white matter tract with a marked defect in the corpus callosum. This tract is mainly formed by axons projecting from layer II/III neurons. HD leads to microtubule bundling defects in the growth cone, the cellular compartment that drives axonal growth. We performed a mass spectrometry-based proteomic analysis of growth cones from WT (HdhQ7/Q7) and HD (HdhQ7/Q111) mice to identify proteins involved in HD-induced phenotypes on axonal growth and on the growth cone microtubule cytoskeleton.
HostingRepository	PRIDE
AnnounceDate	2021-12-08
AnnouncementXML	Submission_2021-12-08_02:58:08.251.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD023885
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yohann Couté
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-29 04:34:10	ID requested
⏵ 1	2021-12-08 02:58:09	announced

Capizzi M, Carpentier R, Denarier E, Adrait A, Kassem R, Mapelli M, Cout, é Y, Humbert S, Developmental defects in Huntington's disease show that axonal growth and microtubule reorganization require NUMA1. Neuron, 110(1):36-50.e5(2022) [pubmed]

submitter keyword: Huntington’s disease, Growth Cone, LC-MS/MS

Virginie Brun
contact affiliation	EDyP
contact email	virginie.brun@cea.fr
lab head
Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023885
     1. Label: PRIDE project
     2. Name: Proteomic analysis of growth cones from WT and HD mice