PXD023834 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS |
Description | Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus induced disease 2019 (COVID-19). Neutrophils play a key role in the lung injury characteristic of non-COVID-19 ARDS and there is also accumulating evidence of neutrophil mediated lung injury in patients who succumb to infection with SARS-CoV-2. We undertook a functional proteomic and metabolomic survey of circulating neutrophil populations, comparing patients with COVID-19 ARDS and non-COVID-19 ARDS to understand the molecular basis of neutrophil dysregulation. Expansion of the circulating neutrophil compartment and the presence of activated low and normal density mature and immature neutrophil populations occurs in ARDS, irrespective of cause. Release of neutrophil granule proteins, neutrophil activation of the clotting cascade and upregulation of the Mac-1 platelet binding complex with formation of neutrophil platelet aggregates is exaggerated in COVID-19 ARDS. Importantly, activation of components of the neutrophil type I interferon responses is seen in ARDS following infection with SARS-CoV-2, with associated rewiring of neutrophil metabolism to promote glutamine utilisation, and the upregulation of antigen processing and presentation. Whilst dexamethasone treatment constricts the immature low density neutrophil population it does not impact upon prothrombotic hyperinflammatory neutrophil signatures. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:18:31.106.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Andrew Howden |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; iodoacetamide derivatized residue |
Instrument | orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-01-26 06:17:37 | ID requested | |
1 | 2021-03-04 14:43:01 | announced | |
⏵ 2 | 2024-10-22 05:18:31 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
ProteomeXchange project tag: Covid-19 |
submitter keyword: ARDS, Type I IFN, SARS-CoV-2, dexamethasone,Neutrophil, COVID-19 |
Contact List
Sarah Walmsley |
contact affiliation | Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK |
contact email | sarah.walmsley@ed.ac.uk |
lab head | |
Andrew Howden |
contact affiliation | University of Dundee |
contact email | a.howden@dundee.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD023834 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023834
- Label: PRIDE project
- Name: A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS