PXD023800 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Myocardial proteome profiling reveals disease- and sex-specific alterations in patients with aortic valve stenosis and mitral valve regurgitation |
Description | Heart valve diseases, such as aortic valve stenosis (AS) and mitral valve regurgitation (MR), are leading causes of heart failure. However, myocardial proteome studies in AS and MR are extremely rare. We profiled the proteome of 75 human left ventricular myocardial biopsies (AS=41, MR=17, controls=17) and detected disease- and sex-specific protein expression alterations. Patients with AS, for example, showed higher abundance of fibrosis-related proteins and lower abundance of proteins related to energy metabolism and protein synthesis capacity with prominent sex differences. This might explain the higher amount of myocardial mass and fibrosis and lower systolic cardiac function especially observed in male AS in our cohort and might help to find specific proteins as treatment targets. Our work provides detailed insight into myocardial protein alterations in AS and MR and expands, in combination with clinical parameters, the understanding of cardiac remodeling in female and male patients, aiming to improve disease- and sex-specific therapy. |
HostingRepository | PRIDE |
AnnounceDate | 2022-12-13 |
AnnouncementXML | Submission_2022-12-13_00:48:12.087.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | MatthiasZiehm |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF-X; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-01-25 08:19:44 | ID requested | |
⏵ 1 | 2022-12-13 00:48:12 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: mitral regurgitation, sex differences, cytoskeleton, aortic stenosis, fibrosis, energy metabolism, proteostasis,heart, extracellular matrix |
Contact List
PhilippMertins |
contact affiliation | Max-Delbrück-Center for Molecular Medicine; Proteomics Platform; Robert-Rössle-Str. 10; 13092 Berlin, Germany |
contact email | philipp.mertins@mdc-berlin.de |
lab head | |
MatthiasZiehm |
contact affiliation | Max-Delbrück-Center for Molecular Medicine (MDC) |
contact email | matthias.ziehm@mdc-berlin.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD023800
- Label: PRIDE project
- Name: Myocardial proteome profiling reveals disease- and sex-specific alterations in patients with aortic valve stenosis and mitral valve regurgitation