PXD023779-2

PXD023779 is an original dataset announced via ProteomeXchange.

Title	CCDC88B affinity proteomic analysis
Description	The CCDC88B gene (11q13) is a risk factor for several chronic inflammatory diseases in humans, including inflammatory bowel disease (IBD), multiple sclerosis and psoriasis. A Ccdc88b mutation in mice conveys protection against pathological inflammation in experimental models of microbial (cerebral malaria) and autoimmune (experimental autoimmune encephalomyelitis) of neuroinflammation and colitis. At the cellular level, loss of Ccdc88b function is phenotypically expressed as a migratory defect in vivo, and a cell mobility defect in vitro in mutant dendritic cells and lymphocytes. At the molecular level, CCDC88B belongs to a family of protein scaffold associated with the cytoskeleton and that feature protein:protein interactions domains. We used a co-immunoprecipitation / mass spectrometry-based approach to identify physical interactions of CCDC88B from mouse thymocytes and BI-141 cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:19:56.434.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John LaCava
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-25 00:24:09	ID requested
1	2024-01-10 04:55:53	announced
⏵ 2	2024-10-22 06:19:56	announced	2024-10-22: Updated project metadata.

10.1038/S42003-023-05751-9;

submitter keyword: mouse, neuroinflammation, thymus, colitis

John LaCava
contact affiliation	The Rockefeller University
contact email	jlacava@rockefeller.edu
lab head
John LaCava
contact affiliation	The Rockefeller University
contact email	lacava@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023779
     1. Label: PRIDE project
     2. Name: CCDC88B affinity proteomic analysis