PXD023763-1

PXD023763 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Modular biomaterials vaccine technology protects against multiple pathogens and septic shock
Description	We have developed a composite infection vaccine technology (ciVAX) assembled from approved products for rapid response to pandemics and biothreat agents. ciVAX consists of an injectable biomaterial scaffold containing factors that recruit, reprogram and release dendritic cells (DC) in vivo. For bacterial infections, ciVAX contains Fc-Mannose-Binding Lectin (FcMBL) microbeads with captured PAMPs fractions from inactivated bacterial cell-wall lysates. ciVAX vaccination generates potent humoral and T cell responses to bacterial antigens, and ciVAX protects mice and pigs against lethal E coli challenge in sepsis and septic shock models
HostingRepository	MassIVE
AnnounceDate	2021-05-29
AnnouncementXML	Submission_2021-05-29_14:07:36.478.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Bogdan Budnik
SpeciesList	scientific name: Escherichia coli; common name: E. coli; NCBI TaxID: 562; scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	Oxidation; Deamidated; Carbamidomethyl
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-22 14:11:33	ID requested
⏵ 1	2021-05-29 14:07:36	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: composite infection vaccine technology (ciVAX), Fc-Mannose-Binding Lectin (FcMBL) microbeads, T cell responses to bacterial antigens

submitter keyword: composite infection vaccine technology (ciVAX), Fc-Mannose-Binding Lectin (FcMBL) microbeads, T cell responses to bacterial antigens

Contact List

David J Mooney
contact affiliation	Harvard John A. Paulson School of Engineering and Applied Sciences
contact email	mooneyd@seas.harvard.edu
lab head
Bogdan Budnik
contact affiliation	Harvard University
contact email	bbudnik@mcb.harvard.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000086751/