PXD023720-3

PXD023720 is an original dataset announced via ProteomeXchange.

Title	Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition
Description	Alveolar type II (ATII) epithelial cells function as stem cells, contributing to alveolar renewal, repair and cancer. Therefore, they are a highly relevant model for studying lung diseases, including acute injury, fibrosis and cancer, in which signals transduced by RAS and transforming growth factor (TGF)-ß play critical roles. To identify downstream molecular events following RAS and/or TGF-ß activation, we performed proteomic analysis using a quantitative label-free approach (LC-HDMSE) to provide in-depth proteome coverage and estimates of protein concentration in absolute amounts. Contact: pjss@soton.ac.uk
HostingRepository	PRIDE
AnnounceDate	2021-02-04
AnnouncementXML	Submission_2021-02-04_02:35:56.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yilu Zhou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	MALDI Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-21 00:00:32	ID requested
1	2021-02-03 23:53:10	announced
2	2021-02-04 00:55:44	announced	2021-02-04: Updated project metadata.
⏵ 3	2021-02-04 02:35:56	announced	2021-02-04: Updated project metadata.

Dataset with its publication pending

submitter keyword: Human Top-down Alveolar type II epithelial cells

Yihua Wang
contact affiliation	University of Southampton
contact email	yw4y14@soton.ac.uk
lab head
Yilu Zhou
contact affiliation	yz3n18@soton.ac.uk
contact email	yz3n18@soton.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD023720

PRIDE project URI

• PRIDE
  1. PXD023720
     1. Label: PRIDE project
     2. Name: Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition