PXD023643 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Changes of the muscle stem cell niche during aging |
Description | During aging, the regenerative capacity of skeletal muscle decreases due to intrinsic changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we used quantitative mass spectrometry to characterize intrinsic changes in the MuSC proteome and remodeling of the MuSC niche during aging. We generated a network connecting age-affected ligands located in the niche and cell surface receptors on MuSCs. Thereby, we revealed signaling via Integrins, Lrp1, Egfr and Cd44 as the major cell communication axes perturbed through aging. We investigated the effect of Smoc2, a secreted protein that accumulates with aging, originating from fibro-adipogenic progenitors. Increased levels of Smoc2 contribute to the aberrant Itgb1/MAPK signaling observed during aging, thereby causing impaired MuSC functionality and muscle regeneration. By connecting changes in the proteome of MuSCs to alterations of their niche, our work will enable a better understanding of how MuSCs are affected during aging. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-10 |
AnnouncementXML | Submission_2021-11-10_04:59:09.040.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Emilio Cirri |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue |
Instrument | Orbitrap Exploris 480; Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-01-17 23:49:39 | ID requested | |
⏵ 1 | 2021-11-10 04:59:09 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Skeletal muscle, stem cells, proteomics, phosphoproteomics, mouse |
Contact List
Alessandro Ori |
contact affiliation | Leibniz Institute on Aging - Fritz Lipmann Institute Jena |
contact email | alessandro.ori@leibniz-fli.de |
lab head | |
Emilio Cirri |
contact affiliation | Leibniz Institute on Ageing Fritz Lipmann Institute Jena |
contact email | emilio.cirri@fli-leibniz.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023643
- Label: PRIDE project
- Name: Changes of the muscle stem cell niche during aging