PXD023526 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Pilot proteomic profiling of blood plasma obtained from lean and obese individuals |
Description | Obesity is a frightening chronic disease, which has tripled since 1975. It is not expected to slow down staying one of the leading cases of preventable death and resulting in an increased clinical and economic burden. Poor lifestyle choices and excessive intake of “cheap calories” are major contributors to obesity, triggering type 2 diabetes, cardiovascular diseases, and other comorbidities. Understanding the molecular mechanisms responsible for development of obesity is essential as it might result in development of early-stage obesity biomarkers, allowing distinguish between metabolic syndromes and anti-obesity targets. The complex nature of this disease, coupled with the phenomenon of metabolically healthy obesity, inspired us to perform data-centric, hypothesis-generating pilot research, aimed to find correlations between parameters of classic clinical blood tests and proteomic profiles of 104 lean and obese subjects. As the result, we assembled patterns of proteins, which presence or absence allows predicting the weight of the patient fairly well. We believe that such proteomic patterns with high prediction power should facilitate the translation of potential candidates into biomarkers of clinical use for early-stage stratification of obesity therapy. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-10 |
AnnouncementXML | Submission_2021-09-09_16:41:16.917.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Olga Kiseleva |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | S-pyridylethyl-L-cysteine; iodoacetamide derivatized residue |
Instrument | Q Exactive HF; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-01-11 10:42:26 | ID requested | |
⏵ 1 | 2021-09-09 16:41:17 | announced | |
Publication List
Kiseleva OI, Arzumanian VA, Poverennaya EV, Pyatnitskiy MA, Ilgisonis EV, Zgoda VG, Plotnikova OA, Sharafetdinov KK, Lisitsa AV, Tutelyan VA, Nikityuk DB, Archakov AI, Ponomarenko EA, Does Proteomic Mirror Reflect Clinical Characteristics of Obesity? J Pers Med, 11(2):(2021) [pubmed] |
Keyword List
submitter keyword: blood plasma, obese, lean, metabolic syndrome, LC-MS/MS |
Contact List
Ekaterina Poverennaya |
contact affiliation | Laboratory of Interactomics of Proteoforms, Institute of Biomedical Chemistry |
contact email | k.poverennaya@gmail.com |
lab head | |
Olga Kiseleva |
contact affiliation | Institute of Biomedical Chemistry |
contact email | olly.kiseleva@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023526
- Label: PRIDE project
- Name: Pilot proteomic profiling of blood plasma obtained from lean and obese individuals