PXD023468-1

PXD023468 is an original dataset announced via ProteomeXchange.

Title	Quantitative Analysis of Lysine Acetylation in A549 Cell Line
Description	C-C Motif Chemokine 18 (CCL18) belongs to the chemokine CC family and is predominantly secreted by M2-tumor associated macrophage (TAMs). It has been reported to be associated with various diseases and malignancies. Previous study showed that CCL18 promotes metastasis by activating downstream kinases. However, it remains unknown whether CCL18 regulates post-translational modifications, other than phosphorylation, during tumorigenesis. Here, we demonstrate that CCL18 is up-regulated in non-small cell lung cancer (NSCLC) and is involved in regulating the lysine acetylome in A549 cells. Using the combination of SILAC labeling and high-efficiency acetylation enrichment methods
HostingRepository	PRIDE
AnnounceDate	2021-02-16
AnnouncementXML	Submission_2021-02-16_02:23:04.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	kong shuai
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-08 02:00:12	ID requested
⏵ 1	2021-02-16 02:23:05	announced

Kong S, Ding L, Fan C, Li Y, Wang C, Wang K, Xu W, Shi X, Wu Q, Wang F, Global analysis of lysine acetylome reveals the potential role of CCL18 in non-small cell lung cancer. Proteomics, 21(7-8):e2000144(2021) [pubmed]

submitter keyword: CCL18

acetylome

non-small cell lung cancer

Fengsong wang
contact affiliation	Anhui Medical University
contact email	fengsongw@ahmu.edu.cn
lab head
kong shuai
contact affiliation	anhui meidical university
contact email	304953412@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023468
     1. Label: PRIDE project
     2. Name: Quantitative Analysis of Lysine Acetylation in A549 Cell Line