PXD023400-1

PXD023400 is an original dataset announced via ProteomeXchange.

Title	Mechanism of disaggregation of Tau fibrils in vivo
Description	The interactome of fibrillar aggregates of the Tau repeat domain fused to YFP (TauRD-Y) was analyzed in HEK293T cells using SILAC. TauRD-Y was immunoprecipitated with anti-GFP antibody from lysates of SILAC-labeled cells expressing TauRD-Y in soluble form (light labeled; L), from cells containing aggregated TauRD-Y in nucleus and cytosol (medium labeled; M), and from cells containing aggregated TauRD-Y mainly localized to the cytoosl (heavy-labeled; H).
HostingRepository	PRIDE
AnnounceDate	2022-12-09
AnnouncementXML	Submission_2022-12-09_07:06:51.729.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	RomanKörner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-04 04:02:22	ID requested
⏵ 1	2022-12-09 07:06:52	announced

Dataset with its publication pending

submitter keyword: Amyloid fibrils

AAA+ chaperones

VCP/P97

disaggregation

prion-like aggregate spreading

F. UlrichHartl
contact affiliation	Max-Planck Institute of Biochemistry, Department of Cellular Biochemistry
contact email	uhartl@biochem.mpg.de
lab head
RomanKörner
contact affiliation	Max-Planck Institute of Biochemistry, Department of Cellular Biochemistry
contact email	rkoerner@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD023400

PRIDE project URI

• PRIDE
  1. PXD023400
     1. Label: PRIDE project
     2. Name: Mechanism of disaggregation of Tau fibrils in vivo