PXD023359-1

PXD023359 is an original dataset announced via ProteomeXchange.

Title	Bacteria initiates inflammaging leading to degenerative disc disease- evidence from host defense mechanism
Description	Inflammaging is an established cause of degenerative disc disease (DDD), the possible triggers being genetic, mechanical, or infective. With rising evidence of subclinical infection and dysbiosis as initiators of degeneration, this study was undertaken to investigate the sequential molecular events associated with bacteria-induced changes in the host leadingto Inflammaging and DDD. Our study has documented increasing evidence for bacteria's role in triggering the innate immune system leading to chronic inflammation and degeneration.
HostingRepository	PRIDE
AnnounceDate	2025-01-08
AnnouncementXML	Submission_2025-01-07_19:40:30.660.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD023359
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Chitraa Tangavel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-04 01:39:29	ID requested
⏵ 1	2025-01-07 19:40:31	announced

10.1007/S00586-021-06826-Z;

10.6019/PXD023359;

submitter keyword: Human, Intervertebral Disc, NP, Infection, HDRP

Dr Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact email	cthangavel@gmail.com
lab head
Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact email	cthangavel@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD023359

PRIDE project URI

• PRIDE
  1. PXD023359
     1. Label: PRIDE project
     2. Name: Bacteria initiates inflammaging leading to degenerative disc disease- evidence from host defense mechanism