PXD023293 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Global Phospho-Proteomic Profiling of Pathway-Level Molecular Alterations in Barrett’s Esophagus |
Description | In the present study, we applied deep, quantitative mass-spectrometry to clinical samples (Barrett’s esophagus and matched adjacent normal biopsies) to gain a mechanistic understanding of the molecular pathways associated with disease progression. From our rich LC/MS profiles, we identified a robust proteomic signature that was able to correctly classify independent samples on disease status. Projection of this same signature against EAC tumor profiles was strongly predictive of survival outcomes, while subsequent comparative analysis with published BE transcriptomic profiles provided independent evidence in support of these results. Further, our phosphoproteomic analysis revealed signaling pathways specifically and significantly altered in BE relative to paired controls, providing some mechanistic insights into the cellular dysregulation of key components of specific processes that likely drives disease progression. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-11 |
AnnouncementXML | Submission_2022-08-11_05:07:27.740.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jarrod Moore |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-12-23 05:17:16 | ID requested | |
⏵ 1 | 2022-08-11 05:07:28 | announced | |
Publication List
Moore J, Hekman R, Blum BC, Lawton M, Lehoux S, Stachler M, Pleskow D, Sawhney MS, Cummings RD, Emili A, Qureshi A, Pilot Study Showing Feasibility of Phosphoproteomic Profiling of Pathway-Level Molecular Alterations in Barrett's Esophagus. Genes (Basel), 13(7):(2022) [pubmed] |
Keyword List
submitter keyword: Biopsy |
Systems Biology |
Mass Spectrometry |
Disease Signature |
Contact List
Andrew Emili |
contact affiliation | Department of Biochemistry at Boston Univeristy School of Medicine |
contact email | aemili@bu.edu |
lab head | |
Jarrod Moore |
contact affiliation | Boston University School of Medicine |
contact email | jmoore5@bu.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD023293 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023293
- Label: PRIDE project
- Name: Global Phospho-Proteomic Profiling of Pathway-Level Molecular Alterations in Barrett’s Esophagus