PXD023227-1

PXD023227 is an original dataset announced via ProteomeXchange.

Title	Adverse Effects of Bisphenol A and its substitute compounds on human SGBS preadipocytes
Description	Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was reported to cause metabolic disruption. Substitute compounds are increasingly emerging, but are not sufficiently investigated. In this study, we aimed to investigate the mode of action of BPA and four of its substitutes during the differentiation of human preadipocytes. Human preadipocytes were exposed to BPA, BPS, BPB, BPF, and BPAF, as well as the PPARγ-antagonist GW9662. After 12 days of differentiation, global protein profiles were assessed using LC-MS/MS-based proteomics.
HostingRepository	PRIDE
AnnounceDate	2021-08-05
AnnouncementXML	Submission_2021-08-05_02:42:16.529.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexandra Schaffert
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-18 07:02:32	ID requested
⏵ 1	2021-08-05 02:42:16	announced
2	2021-08-05 22:02:33	announced	2021-08-06: Updated project metadata.

10.1016/J.ENVINT.2021.106730;

submitter keyword: human, adipocytes, bpa, bisphenol a, SGBS

Kristin Schubert
contact affiliation	Helmholtz-Centre for Environmental Research – UFZ Leipzig, Germany
contact email	kristin.schubert@ufz.de
lab head
Alexandra Schaffert
contact affiliation	Helmholtz-Centre for Environmental Research
contact email	alexandra.schaffert@ufz.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023227
     1. Label: PRIDE project
     2. Name: Adverse Effects of Bisphenol A and its substitute compounds on human SGBS preadipocytes