PXD023135-1

PXD023135 is an original dataset announced via ProteomeXchange.

Title	Dysregulation of the cGAS/STING axis due to COPI-deficiency
Description	COPA syndrome is caused by mutations in the COP- subunit of coatomer protein complex 1 (COP-I), which participates in retrograde vesicular trafficking of proteins from the Golgi to the endoplasmic reticulum (ER). Disease manifests early in life with arthritis, lung disease, kidney dysfunction and systemic inflammation associated with NFB and type I interferon. We sought to identify the upstream innate immune sensor that drives inflammation in COPA syndrome.
HostingRepository	PRIDE
AnnounceDate	2022-04-07
AnnouncementXML	Submission_2022-04-06_17:22:50.925.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-15 01:41:35	ID requested
⏵ 1	2022-04-06 17:22:51	announced

Dataset with its publication pending

submitter keyword: COPA syndrome, inflammation, cyclic GMP-AMP-Synthase (cGAS), Stimulator of interferon genes (STING), type I interferons, retrograde trafficking

A/Prof Seth Masters
contact affiliation	Laboratory Head Walter and Eliza Hall Institute of Medical Research 1G Royal Parade, Parkville, AUS 3052
contact email	masters@wehi.edu.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD023135

PRIDE project URI

• PRIDE
  1. PXD023135
     1. Label: PRIDE project
     2. Name: Dysregulation of the cGAS/STING axis due to COPI-deficiency