PXD023012 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Dilution Series imputation, LC MS/MS |
Description | Missing values in proteomic data sets have real consequences on downstream data analysis and reproducibility. Although several imputation methods exist to handle missing values, no single imputation method is best suited for a diverse range of data sets, and no clear strategy exists for evaluating imputation methods for large-scale DIA-MS data sets, especially at different levels of protein quantification. To navigate through the different imputation strategies available in the literature, we have established a workflow to assess imputation methods on large-scale label-free DIA-MS data sets. We used three DIA-MS data sets with real missing values to evaluate eight different imputation methods with multiple parameters at different levels of protein quantification; dilution series data set, a small pilot data set, and a larger proteomic data set. |
HostingRepository | PRIDE |
AnnounceDate | 2021-05-07 |
AnnouncementXML | Submission_2021-05-06_23:19:42.277.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Kruttika Dabke |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-12-09 01:34:56 | ID requested | |
⏵ 1 | 2021-05-06 23:19:42 | announced | |
Publication List
Dabke K, Kreimer S, Jones MR, Parker SJ, A Simple Optimization Workflow to Enable Precise and Accurate Imputation of Missing Values in Proteomic Data Sets. J Proteome Res, 20(6):3214-3229(2021) [pubmed] |
Keyword List
submitter keyword: Imputation, ovarian cancer, DIA-MS, Dilution series |
Contact List
Sarah Parker |
contact affiliation | Cedars-Sinai Medical Center |
contact email | sarah.parker@cshs.org |
lab head | |
Kruttika Dabke |
contact affiliation | Cedars-Sinai Medical Center |
contact email | kruttika.dabke@cshs.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/05/PXD023012 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023012
- Label: PRIDE project
- Name: Dilution Series imputation, LC MS/MS