PXD022974 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair |
Description | Emerging evidence points to post translational modification (PTM) of nuclear lamins as a key regulator of their diverse roles in nuclear organization, chromatin stability, DNA repair, and cell cycle progression. However, the functions of many of these PTMs remain uncharacterized. Here, we demonstrate a role for acetylation at lysine 134 on lamin B1 in slowing the G1 to S cell cycle transition by inhibiting resolution of DNA damage by canonical nonhomologous end joining. |
HostingRepository | PRIDE |
AnnounceDate | 2021-03-04 |
AnnouncementXML | Submission_2021-03-04_12:46:58.963.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Laura Murray |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-12-07 04:46:21 | ID requested | |
⏵ 1 | 2021-03-04 12:46:59 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Lamin B1, lamin, acetylation, DNA repair, TurboID, nonhomologous end joining |
Contact List
Ileana M. Cristea |
contact affiliation | Department of Molecular Biology, Princeton University |
contact email | icristea@princeton.edu |
lab head | |
Laura Murray |
contact affiliation | Princeton University |
contact email | lamurray@princeton.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/01/PXD022974 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022974
- Label: PRIDE project
- Name: Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair