PXD022958-1

PXD022958 is an original dataset announced via ProteomeXchange.

Title	CSF chitinase 3-like 2 is associated with disability progression in patients with progressive multiple sclerosis
Description	Background: We aimed to identify long-term prognostic protein biomarkers associated with disease progression in patients with progressive multiple sclerosis (MS). Methods: Cerebrospinal fluid (CSF) samples were obtained from a discovery cohort of 28 patients with progressive MS who participated in a placebo-controlled clinical trial with interferon-beta. Patients were classified into high and low disability progression phenotypes according to numeric and step-based progression rates. Protein abundance was measured by shotgun proteomics using liquid chromatographic and mass spectrometric analysis. Selected proteins from the discovery cohort were quantified by parallel reaction monitoring in CSF samples from an independent validation cohort of 41 patients with progressive MS classified also into high and low disability progression phenotypes. Results: Out of 1582548 CSF proteins identified in the discovery cohort, ten proteins were selected for validation based on the number of significant differences observed in the progression rates between patients with high and low disability progression: SPATS2-like protein (SPATS2L), Chitinase 3-like 2 (CHI3L2), plasma serine protease inhibitor (SERPINA5), Metallothionein-3 (MT3), Phospholipase D4 (PLD4), Beta-hexosaminidase (HEXB), Neurexophilin-1 (NXPH1), Adipocyte enhancer-binding protein 1 (AEBP1), Cathepsin L1 (CTSL), and Lipopolysaccharide-binding protein (LBP). Only CHI3L2 was validated, exhibiting significantly higher CSF protein levels and CSF protein levels were significantly higher in patients with high disability progression compared to patients with low disability progression. CSF CHI3L2 levels showed good performance to discriminate between progressive MS patients with high and low disability progression. Conclusions: Although further confirmatory studies are needed, we propose CSF CHI3L2 as a prognostic protein biomarker associated with disability progression in progressive MS patients.
HostingRepository	PRIDE
AnnounceDate	2021-11-03
AnnouncementXML	Submission_2021-11-03_07:31:28.070.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eva Borràs
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-07 03:09:47	ID requested
⏵ 1	2021-11-03 07:31:28	announced
2	2024-10-22 05:30:10	announced	2024-10-22: Updated project metadata.

Comabella M, Sastre-Garriga J, Borras E, Villar LM, Saiz A, Mart, í, nez-Y, é, lamos S, Garc, í, a-Merino JA, Pinteac R, Fissolo N, S, á, nchez L, ó, pez AJ, Costa-Frossard L, Blanco Y, Llufriu S, Vidal-Jordana A, Sabid, ó E, Montalban X, CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm, 8(6):(2021) [pubmed]

submitter keyword: multiple sclerosis

Eduard Sabido
contact affiliation	CRG, UPF
contact email	eduard.sabido@crg.eu
lab head
Eva Borràs
contact affiliation	UPF
contact email	eva.borras@upf.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022958
     1. Label: PRIDE project
     2. Name: CSF chitinase 3-like 2 is associated with disability progression in patients with progressive multiple sclerosis