PXD022957 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative Phosphoproteomics for Prolonged Cabozantinib-Treated Renal Cell Carcinoma Cells |
| Description | Patients with recurrent or metastatic renal cell carcinoma (mRCC) usually develop resistance to targeted tyrosine kinase inhibitors (TKI). Recently, FDA-approved cabozantinib is found to inhibit pathways linked to TKI resistance. Although cabozantinib is believed to be a new gold standard in managing TKI-resistant mRCC, it is still possible that mRCC can develop resistance to prolonged cabozantinib treatment by changing intracellular phosphorylation dynamics. In this study, 786-O was used for prolonged cabozantinib treatment for more than 4 months. Using quantitative phosphoproteomic approach, we tried to identified dysregulated pathways in prolonged cabozantinib treatment |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-03 |
| AnnouncementXML | Submission_2026-03-02_22:44:08.941.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Wei-Chi Ku |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2020-12-07 03:09:44 | ID requested | |
| ⏵ 1 | 2026-03-02 22:44:09 | announced | |
Publication List
Keyword List
| submitter keyword: Human, renal cell carcinoma, cabozantinib |
Contact List
| Wei-Chi Ku |
|---|
| contact affiliation | School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan |
| contact email | 089052@mail.fju.edu.tw |
| lab head | |
| Wei-Chi Ku |
|---|
| contact affiliation | Fu Jen Catholic University |
| contact email | 089052@mail.fju.edu.tw |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD022957 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022957
- Label: PRIDE project
- Name: Quantitative Phosphoproteomics for Prolonged Cabozantinib-Treated Renal Cell Carcinoma Cells
