PXD022926-2
PXD022926 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Nano-LC-MS/MS proteomics in amniotic fluid from CAKUT patients |
Description | The objective of the present work was to identify new renal proteins responsible for Congenital Anomalies of the Kidney and of the Urinary Tract (CAKUT pathophysiology). We conducted a comparative LC-MS/MS-based proteomics analysis of amniotic fluids (AF) collected from non-severe CAKUT (ns-CAKUT; n=19), severe CAKUT (s-CAKUT; n=14), and healthy controls (cont; n=22) fetuses. We identified a total of 224 gestational age independent proteins that were significantly different in abundance when comparing (one-way ANOVA corrected p<0.05) the 3 groups of amniotic fluids 2 by 2. We identified 8 gestational-age independent proteins that were in common when comparing the 3 groups two by two, and that were considered as associated to both CAKUT onset and CAKUT severity. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_09:05:28.675.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mylène CAMUS |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-12-04 07:44:37 | ID requested | |
1 | 2023-09-26 04:33:23 | announced | |
⏵ 2 | 2023-11-14 09:05:37 | announced | 2023-11-14: Updated project metadata. |
Publication List
F, é, dou C, Camus M, Lescat O, Feuillet G, Mueller I, Ross B, Bul, é, on M, Neau E, Alves M, Goudoun, é, che D, Breuil B, Boizard F, Bardou Q, Casemayou A, Tack I, Dreux S, Batut J, Blader P, Burlet-Schiltz O, Decramer S, Wirth B, Klein J, Saulnier-Blache JS, Buffin-Meyer B, Schanstra JP, Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies plastin 3 as a protein involved in glomerular integrity. J Pathol, 254(5):575-588(2021) [pubmed] |
Keyword List
submitter keyword: chronic kidney disease,CAKUT, proteomics, plastin-3, amniotic fluid |
Contact List
Joost-Peter Schanstra | |
---|---|
contact affiliation | I2MC Inserm U1048 - Toulouse |
contact email | joost-peter.schanstra@inserm.fr |
lab head | |
Mylène CAMUS | |
contact affiliation | CNRS |
contact email | mylene.camus@ipbs.fr |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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