PXD022832 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Cocaine self-administration induces divergent protein expression in the nucleus accumbens of male and female mice to eliminate basal sex differences |
Description | Substance use disorder (SUD) is a chronic neuropsychiatric condition characterized by long-lasting alterations in the neural circuitry regulating reward and motivation. Substantial work has focused on characterizing the molecular substrates which underlie these persistent changes in neural function and behavior; however, this work has overwhelmingly focused on male subjects, despite mounting clinical and preclinical evidence that females demonstrate dissimilar progression to SUD and responsivity to drugs of abuse, such as cocaine. Here, we show that sex is a critical biological variable that defines drug-induced plasticity in the NAc. Using quantitative mass spectrometry, we assessed the protein expression patterns altered by cocaine self-administration and demonstrate unique molecular profiles between males and females. We show that 1. Cocaine self-administration induces non-overlapping protein expression patterns in males and females and 2. Cocaine specifically acts on baseline sexual dimorphisms to exert these effects. Critically, we find that cocaine administration blunts not only basal sex-differences in the accumbens proteome, but also the pre-existing sex differences in behavior for natural rewards. Together, these data suggest that chronic cocaine is capable of rewriting baseline proteomic function to maintain cocaine-specific behaviors. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-09 |
AnnouncementXML | Submission_2021-09-09_14:00:53.927.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Erin Calipari |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-12-01 02:25:27 | ID requested | |
⏵ 1 | 2021-09-09 14:00:54 | announced | |
Publication List
L, รณ, pez AJ, Johnson AR, Euston TJ, Wilson R, Nolan SO, Brady LJ, Thibeault KC, Kelly SJ, Kondev V, Melugin P, Kutlu MG, Chuang E, Lam TT, Kiraly DD, Calipari ES, Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens. Commun Biol, 4(1):883(2021) [pubmed] |
Keyword List
submitter keyword: nucleus accumbens, mouse, mus musculus, cocaine |
Contact List
Erin S. Calipari |
contact affiliation | Vanderbilt UniversityAssistant Professor of Pharmacology Assistant Professor of Pharmacology, Molecular Physiology and Biophysics Vanderbilt Brain Institute Vanderbilt Center for Addiction Research Vanderbilt Institute for Infection, Immunology and Inflammation |
contact email | erin.calipari@vanderbilt.edu |
lab head | |
Erin Calipari |
contact affiliation | Vanderbilt University |
contact email | calipari.lab@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022832
- Label: PRIDE project
- Name: Cocaine self-administration induces divergent protein expression in the nucleus accumbens of male and female mice to eliminate basal sex differences